Publicly available 'Integrative Genomics Viewer can incorporate multiple types of data and rapidly view them at any level of resolution

Researchers are collecting vast amounts of diverse genomic data with ever-increasing speed, but effective ways to visualize these data in an integrated manner have lagged behind the ability to generate them. To address this growing need, researchers at the Broad Institute have developed the Integrative Genomics Viewer (IGV), a novel and freely available visualization tool that helps users simultaneously integrate and analyze different types of genomic data, and gives them the flexibility to zoom in on a specific genomic region of interest or to pan out for a broad, whole genome view.

Blacksburg, Va. – Researchers from the Virginia Bioinformatics Institute (VBI) at Virginia Tech have identified the region of a large family of virulence proteins in oomycete plant pathogens that enables the proteins to enter the cells of their hosts. The protein region contains the amino acid sequence motifs RXLR and dEER and has the ability to carry the virulence proteins across the membrane surrounding plant cells without any additional machinery from the pathogen. Once inside the plant cell, the proteins suppress the immune system of the plant allowing the infection to progress. The work, which focused on the virulence protein Avr1b from the soybean plant pathogen Phytophthora sojae, is published in the advance online edition of The Plant Cell.*

Washington, DC—The field of personalized cancer research and treatment grows with each day. And a new collaboration with Washington's largest biomedical research organization and an international research and biobanking company is contributing to that growth.

New Haven, Conn. — Time-lapse videos and computer simulations provide the first concrete molecular explanation of how a cell flexes tiny muscle-like structures to pinch itself into two daughter cells at the end of each cell division, according to a report in Science Express.

CHAMPAIGN, Ill. — Using computer simulations, researchers at the University of Illinois have demonstrated a strategy for sequencing DNA by driving the molecule back and forth through a nanopore capacitor in a semiconductor chip. The technique could lead to a device that would read human genomes quickly and affordably.

Berkeley -- In the middle of the South Pacific, about 12 miles west of Tahiti, is a tropical island that soon will emerge as a model ecosystem, thanks to the efforts of a U.S.-French research team led by University of California, Berkeley, biologists.

Seeing proteins in their natural environment and interactions inside cells has been a long-standing goal. Using an advanced microscopy technique called cryo-electron tomography, researchers from the European Molecular Biology Laboratory [EMBL] have visualised proteins responsible for cell-cell contacts for the first time. In this week’s issue of Nature they publish the first 3D image of human skin at molecular resolution and reveal the molecular Velcro-like organisation that interlinks cells.

Smallpox is older than thought, according to results of a new technique reported in the Sept. 24 issue of the Proceedings of the National Academy of Sciences by researchers from Lawrence Livermore National Laboratory and the Centers for Disease Control (CDC).

Genes and disease? It's what you do with what you have

A new study published in Nature Genetics on Sunday 16 September 2007 show that common, complex diseases are more likely to be due to genetic variation in regions that control activity of genes, rather than in the regions that specify the protein code.

Blacksburg, Va. – An international team of scientists has produced a new type of rice that grows better and uses water more efficiently than other rice crops. Professor Andy Pereira at the Virginia Bioinformatics Institute (VBI) has been working with colleagues in India, Indonesia, Israel, Italy, Mexico and The Netherlands to identify, characterize and make use of a gene known as HARDY that improves key features of this important grain crop. The research, which was recently published in the Proceedings of the National Academy of Sciences, shows that HARDY contributes to more efficient water use in rice, a primary source of food for more than half of the world’s population. *